SELPHYL® PRFM

Treatment for Under-Eyes, Skin & Scalp

If you have been curious about platelet-based treatments but want an option designed to stay where it is placed, Selphyl® PRFM may be worth exploring. The Selphyl® System prepares Platelet-Rich Fibrin Matrix (PRFM), an autologous treatment made from a small sample of your own blood and designed to support the appearance of smoother, healthier-looking skin

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ABOUT SELPHYL PRFM

WHAT IT IS

Selphyl® is a closed-tube collection and processing system used to prepare Platelet-Rich Fibrin Matrix from a small blood sample. PRFM is sometimes described as an evolution of PRP. Both begin by concentrating platelets from your own blood, but Selphyl adds a second step that converts the liquid platelet concentrate into a flexible, three-dimensional fibrin matrix.

HOW IT WORKS

The entire process happens in a single visit and takes roughly 30 to 45 minutes from blood draw to placement:

1.      Blood draw and separation. Your provider draws a small vial of blood into a Selphyl tube containing a gel separator and an anticoagulant. The tube is spun in a centrifuge, which separates the platelet-rich plasma from red and white blood cells.

2.      Matrix conversion. The platelet-rich layer is transferred into a second tube containing a precise amount of calcium chloride. Over the next several minutes, the plasma transitions from a liquid into a soft, gel-like fibrin matrix.

3.      Placement. Depending on your personalized treatment plan, PRFM is placed beneath the skin with a fine needle or cannula (common for the under-eye area and scalp) or applied topically into the micro-channels created during a microneedling session.

4.      Gradual release. The fibrin matrix is designed to act as a reservoir, holding platelets in place so growth factors are released over several days rather than hours. This sustained contact is how PRFM is intended to support the skin's natural renewal processes for a smoother, more refreshed appearance over time.

WHAT TO EXPECT

Immediately after treatment, you may notice temporary fullness from the fluid itself, which typically settles within one to two days. Any gradual changes in skin texture and tone tend to appear between weeks four and twelve. For the under-eye area and scalp, providers commonly recommend an initial series of three sessions spaced four to six weeks apart, followed by maintenance sessions once or twice a year. Results vary from person to person, and your provider will personalize your series.

FAQS

  • PRFM is prepared from your own blood in a closed-tube system. As with any injectable or microneedling treatment, potential side effects include temporary swelling, bruising, redness, or tenderness. Your provider will review the risks, benefits, and your health history at your consultation so you can make an informed decision.

  • Both start with platelets concentrated from your own blood. PRP remains a liquid, while Selphyl PRFM converts the plasma into a soft fibrin matrix designed to hold platelets in place and release growth factors gradually over several days.

  • Providers commonly recommend an initial series of three sessions spaced four to six weeks apart, followed by maintenance once or twice a year, tailored to your goals and how your skin responds.

  • Downtime is minimal. Expect mild swelling for a day or two, especially under the eyes, and possible pinpoint bruising that typically fades within a week.

  • Any initial fullness from the fluid settles within one to two days. Gradual changes in texture and tone, if they occur, tend to become noticeable between weeks four and twelve, with results varying from person to person.

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Curious whether Selphyl PRFM at Invoque Aesthetics. is right for you?

Our licensed providers will take the time to understand your goals and build a personalized treatment plan, whether that includes PRFM on its own, PRFM with microneedling, or another approach that suits your skin.

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Disclaimer: Selphyl® PRFM is offered for cosmetic and wellness purposes only and is not intended to diagnose, treat, cure, or prevent any disease or medical condition, including hair loss. Information on this page is educational and does not replace a consultation with a licensed provider. Results vary and individual outcomes differ; no specific result is guaranteed. A consultation and health history review are required before treatment. Selphyl® is a registered trademark of its respective owner.